Description Clomiphene citrate    It is used to stimulate the development of ovarian follicles when normal ovulation does not occur.It  appears to work by increasing the output of the hormones FSH (follicle-stimulating hormone) and LH (luteinizing hormone), which stimulate the ovary to cause follicle growth so that an egg may be released at mid-cycle.   Doctors use clomiphene citrate to treat infertility in females. Sometimes, however, they may also prescribe it off-label for males with infertility. Infertility can affect both males and females. According to the National Institute for Child Health and Human DevelopmentTrusted Source, infertility results from: male reproductive issues one-third of the time female reproductive issues one-third of the time unknown issues or both male and female reproductive issues one-third of the time